Treatment Efficacy Score (TES) can capture the relative efficacy of one treatment (e.g. experimental treatment) over the other (e.g. standard of care) by analyzing the distribution of continuous Residual Cancer Burden (RCB) score. We developed three independent methods to calculate TES, that could be tested here.
Residual Cancer Burden could be calculated here.
The applied R scripts are available here.
Developers:
Michal Marczyk, Silesian University of Technology, Gliwice, Poland
Anna Mrukwa, Silesian University of Technology, Gliwice, Poland
Lajos Pusztai, Yale Cancer Center, New Haven, CT, USA
Publication:
Marczyk M, Mrukwa A, Yau C, Wolf D, Chen Y-Y, Balassanian R, Nanda R, Parker BA, Krings G, Sattar H, Zeck JC, Albain KS, Boughey JC, Liu MC, Elias AD, Clark AS, Venters SJ, Shad S, Basu A, Asare SM, Buxton M, Asare AL, Rugo HS, Perlmutter J, DeMichele AM, Yee D, Berry DA, van ’t Veer L, Symmans WF, Esserman L, Pusztai L: Treatment Efficacy Score - continuous residual cancer burden-based metric to compare neoadjuvant chemotherapy efficacy between randomized trial arms in breast cancer trials. Annals of Oncology 2022
https://doi.org/10.1016/j.annonc.2022.04.072